Major Depressive Disorder (depression) is a mental disorder with symptoms including low mood, low self-esteem and loss of pleasure. Approximately 14.8 million patients in the US are affected by depression. Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly used in patients to treat depression, as well as anxiety, OCD and other CNS-related indications. In 2005 SSRIs became the most prescribed drugs in the US. While they are remarkably useful, one of their serious side-effects is increasing suicide and suicidal thoughts among treated individuals.
Through a novel statistical analysis of the FDA’s adverse events database,