METHODS FOR PROGRAMMING DIFFERENTIATED CELLS INTO HEMATOPOIETIC STEM CELLS

This technology defines a specific combination of transcription factors that can program hemogenesis in fibroblasts. The blood system is continuously replenished from a rare population of hematopoietic stem cells (HSCs) that balance self-renewal and differentiation. Transplantation of HSCs is utilized cell therapy for a range of genetic and acquired disorders. However, allogeneic transplantation depends on genetic matching to avoid graft vs. host disease as well as graft rejection, and even matched grafts are still associated with high risk. Furthermore, there are also limited quantities of available material especially in cord