Research

Protein ubiquitination, a multi-step process utilizing a cascade of three enzyme classes (E1, E2 and E3), tightly regulates cellular protein turnover. It plays a key role in cellular proliferation and inflammation and is associated with a multitude of diseases, including cancer, metabolic disorders, and muscle and nerve degeneration. Dr. ...

The GFP-TCR mouse has been constructed such that all its T-cells have a receptor that recognizes green florescent protein (GFP). Such GFP-specific T-cells can be easily removed from the mouse and injected into other target/study mice.  These cells subsequently home to any cell that is expressing GFP and kill the ...

This technology relates to a Human Cytomegalovirus (HCMV) neutralizing monoclonal antibody that is significantly more potent than the currently marketed alternative Cytogam™. HCMV infection is typically unnoticed in healthy people, but can be life-threatening for the immunocompromised, such as HIV patients, organ transplant recipients, or newborn infants. Congenital infection with HCMV ...

This technology allows the identification of a new class of antiviral drugs that inhibit the transmission of the Human Immunodeficiency Virus (HIV) through the virological synapse. Although there are several effective treatments for HIV, it continues to remain an incurable condition that leads to failure and death in the absence of ...

Seized, counterfeit goods in the United States in 2012 were estimated to be worth over $1.30 billion. Current marking techniques can be recovered, copied and illegally used to mark counterfeited goods. To control this increasing problem, reliable counterfeit-resistant techniques are required. Scientists Carter Bancroft and Catherine Clelland ...