Research

Lymphocytes (B-cells and T-cells) are critical components to the immune system and are used to mount a defense against a foreign antigen.  Unlike B-cells, when activated trigger the production of antibodies to address the antigen, T-cell activation leads to the release of cytokines that regulate B-cells and other aspects of ...

Elucidating causal relationships between the components within complex networks has impact in commercial and research applications.  For example, the ability to understand causal relationships of the components that determine stock prices can predict how the stock market will behave.  In biomedical research, knowing the relationships between the genes within complex ...

Protein ubiquitination, a multi-step process utilizing a cascade of three enzyme classes (E1, E2 and E3), tightly regulates cellular protein turnover. It plays a key role in cellular proliferation and inflammation and is associated with a multitude of diseases, including cancer, metabolic disorders, and muscle and nerve degeneration. Dr. ...

This technology relates to a Human Cytomegalovirus (HCMV) neutralizing monoclonal antibody that is significantly more potent than the currently marketed alternative Cytogam™. HCMV infection is typically unnoticed in healthy people, but can be life-threatening for the immunocompromised, such as HIV patients, organ transplant recipients, or newborn infants. Congenital infection with HCMV ...

This technology allows the identification of a new class of antiviral drugs that inhibit the transmission of the Human Immunodeficiency Virus (HIV) through the virological synapse. Although there are several effective treatments for HIV, it continues to remain an incurable condition that leads to failure and death in the absence of ...

Seized, counterfeit goods in the United States in 2012 were estimated to be worth over $1.30 billion. Current marking techniques can be recovered, copied and illegally used to mark counterfeited goods. To control this increasing problem, reliable counterfeit-resistant techniques are required. Scientists Carter Bancroft and Catherine Clelland ...