Therapeutic

Scientists in Drs. Hoffman and Chaurasia’s laboratories have developed a novel approach to substantially expand the numbers of functional Cord blood (CB) hematopoietic stem cells (HSCs) while maintaining true stem cell engraftment capability. Cord blood (CB) cells that express CD34 have extensive hematopoietic capacity and rapidly ...

Fibrotic healing, which can cause scarring, results from the persistence of myofibroblasts. Myofibroblasts are characterized by excess cell surface expression of integrin alpha-v-beta-5 that participates in generating fibrosis through increased cell adhesion and by direct activation of the fibrotic growth factor, ...

Human cells have a multitude (hundreds to thousands) of mitochondria organelles, each carrying multiple circular mtDNA. Mutations in mtDNA can cause developmental and metabolic disorders and play a role in age-related neurological disorders, such as Alzheimer’s and Parkinson’s disease. While sequencing of nuclear DNA has become increasingly easier and less expensive, ...

Crohn’s Disease (CD) is a chronic relapsing/remitting inflammatory disease of the gastrointestinal tract affecting about 800,000 patients in the US and Europe alone with rising incidence rates. In addition to reduced quality of life for CD patients, the chronic inflammation associated with CD ultimately leads to neoplasia, strictures, abscesses, and ...

Thyroid cancer afflicts upwards of 60,000 patients/year in the United States and the incidence rate is rising worldwide. The current standard of care includes surgical thyroidectomy followed by radioactive iodine ablation to destroy any remaining thyroid tissue. As thyroid cancer patients ...

An effective way to protect against influenza infection is through vaccination with attenuated influenza virus. However, due to reassortment, co-infection of an individual with a live attenuated vaccine strain and a wild-type strain of influenza may enable formulation of replication-competent virus carrying the vaccine derived hemagglutinin, to which an infected ...

Resistance to PI3 kinase pathway inhibitors can occur through changes in cancer signaling pathways. “Priming” with subtherapeutic doses bortezomib leads to activation of and reliance on the PI3 kinase pathway, making cancers susceptible to PI3 kinase pathway inhibitors. Dr. Ross Cagan and members of his laboratory at Mount Sinai’s Center ...

Phelin-McDermid Syndrome (PMS) is a rare genetic syndrome, with a wide range of severity of symptoms, including intellectual disabilities, sleep disorders, and seizures, as well as motor and vocalization symptoms. PMS is caused by disruption of the SHANK3/ProSAP2 gene on the terminal of chromosome 22. Approximately 600 cases are known ...

It has long been known that estrogen function in women decreases with age. While estrogen levels are decreased in aging, the levels remain sufficient to stimulate estrogen receptors, suggesting that the reason for the insensitivity to estrogen is due to the decrease in number and function of estrogen receptors that ...

This technology describes a method that increases the ability of paramyxoviruses to encode a large foreign antigen for development of vaccines. Recombinant paramyxoviruses encoding small foreign antigens have been successful at eliciting specific cellular and immune responses and some have also been used as oncolytic viruses. Paramyxoviruses are single stranded RNA ...