Our Partners

Our relationships with industry provide access to partnering and funding opportunities.

Corporations and other innovation focused institutions are increasingly looking to engage with academic research partners. Pharmaceutical corporations solicit specific research projects from medical universities based on gaps in drug discovery pipeline. Industry collaborations formed with Mount Sinai faculty should expedite inventions from discovery to the clinical phase as well as provide relevant research funding.

Here are some of the major pharmaceutical programs we consistently work with to match Mount Sinai researchers with opportunities.

Blue Mountain Technologies

Blue Mountain Technologies is an internal business unit, managed by Mount Sinai Innovation Partners, responsible for bringing Mount Sinai’s growing portfolio of diagnostics, medical devices and research tools to market through commercial partnerships.

Products

Clone Target Immunogen Isotype Reactivity IHC West Elisa
12F4 Beta-amyloid 42 Beta-amyloid 42 C-term., and specific for isoform ending at the 42nd amino acid IgG1 Human and mouse
9C4 Beta-amyloid 43 Beta-amyloid 43 C-term., and specific for isoform ending at the 43rd amino acid IgG1 Human and mouse
11A50-B-10 beta-amyloid 40 Beta amyloid 40 C-term., and specific for isoform ending at the 40th amino acid IgG1 Human and mouse
12F4 Beta-amyloid 42 Beta-amyloid 42 C-term., and specific for isoform ending at the 42nd amino acid IgG1 Human and mouse
2A9 PLZF Human PLZF – GST fusion protein IgG2a Human and mouse West, IP, and IF
35D5 LRP5 Cytoplasmic domain of LRP5 IgG1 Human and mouse West, IP, and IF
1C10 LRP6 Cytoplasmic domain of LRP6 IgG1 Human and mouse West, IP, and IF
29D1 WHSC1/NSD2 Human WHSC1/NSD2 – GST fusion protein, a.a. 1-647 human GST IgG2a Human
17C2 IRF3 Mouse EKLF (KLF1) IgG1 Human West and IF
6B3 EKLF Mouse EKLF (KLF1) IgG3 Human and mouse
24 E6 BRCA1 Human BRCA1 a.a. 1600-1749 IgG2b Human West, IP, and IF
17B5 NPC1 Human NPC-1 fragment conjugated to a carrier protein IgG1 Human
1C3 RIG-I IgG1 Human West and IP
9A2 KLF6 (splice variant 1) Human KFL6 splice variant 1 recombinant protein IgG2a Human
2A2 KLF6 Human KLF6 synthetic peptide IgG1 Human
22B3 RNF5 Human full length recombinant RNF5 IgG1 Human and mouse
3D11 Advanced Glycation Endproducts (AGE)-MG Methylglyoxal-modified ovalbumin (OA)
3A11 GluR2, 4 Recombinant fusion protein trpE-GluR2 IgG2a Human, monkey and rat
A32-F8 NMDAR2A Human NMDA2A fusion protein Mouse
A3-2D10 NMDAR2A Human NMDAR2A fusion protein IgG1 Human, monkey, rat and canine
A3-6B10 NMDAR2A Human NMDAR2A fusion protein Mouse
B3-12B11 NMDAR2A Human NMDA2A fusion protein IgG1 Human, monkey, rat and canine
3B3-A11 GluR3 Fusion protein encompassing the N-terminal region of the rat GluR3 IgG1k Human, monkey and rat
5C4 NMDA1a+d splice variant Rat NMDA1a+d fusion protein Mouse
35A9 Glutamate Transporter EAAC1 Synthetic peptide corresponding to aa 161-177 of the rat glutamate transporter EAAC1 sequence IgG2b Human and rat
Material Description References
LX-1 and LX-2 Cells Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing interest in developing antifibrotic therapies, there is a need for cell lines that preserve the in vivo phenotype of human HSCs to elucidate pathways of human hepatic fibrosis. We established and characterised two human HSC cell lines termed LX-1 and LX-2, and compared their features with those of primary human stellate cells. LX-1 and LX-2 human HSC lines provide valuable new tools in the study of liver disease. Both lines retain key features of HSCs. Two unique advantages of LX-2 are their viability in serum free media and high transfectability. Xu et al. Gut, 54, 142, 2005.
LSC Cells LSC cells are derived from LS174T human colonic cancer cells. LSC cells express only the truncated carbohydrate antigen Tn (GalNAca-Ser/Thr) and sialyl-Tn on their mucin molecules. LSC cells represent the first example of a non-hematopoietic cell line which lacks core 1 beta3-Gal-transferase activity, which is why they are incapable of forming the common mucin O-glycan core structures and are committed to synthesizing the short Tn and STn oligosaccharides. LSC cells provide a useful model for colon and other types of cancer. Brockhausen et al. Glycoconjugate Journal, 15, 595, 1998.
SOD-1 Transgenic Mice These transgenic mice express a mutant form of the SOD-1 gene which contains the G86R missense mutation in exon 4 and is driven by the endogenous promoter. This mutation is prevalent in a subset of patients with familial amyotrophic lateral sclerosis (FALS). Ripps et al. PNAS, 93, 689, 1995
LRRK2-wt BAC Mouse PARK8/LRRK2 (leucine-rich repeat kinase 2) was recently identified as a causative gene for autosomal dominant Parkinson’s disease (PD), with LRRK2 mutation G2019S linked to the most frequent familial form of PD. LRRK2-wt mice overexpress full-length LRRK2, have elevated striatal dopamine (DA) release with unaltered DA uptake and result in hyperactive mice with enhanced performance in motor function tests. This mouse is ideal for studying PD, especially when paired/contrasted with the LRRK2-G2019S BAC mouse. Li et al. J. Neurosci, 30, 1788, 2010.
Floxed CREB1 Mouse These mice have LoxP sites spanning most of the coding region of the CREB1 gene. They are homozygous for this mutation and have been shown to support Cre-driven knockdown of CREB1 mRNA and protein. This mouse can be used to study the role of CREB, a ubiquitously expressed transcription factor, in diverse physiological functions in numerous organs and tissues in which CREB has been implicated. Cao et al. PNAS, 107, 17011, 2010
Viral Set Recombinant Protein Expression vector for vSet. Viruses encode a conserved SET domain methyltransferase, termed vSET, that functions to suppress host transcription by methylating histone H3 at lysine 27 (H3K27), a mark for eukaryotic gene silencing. Wei et al. Proc Natl Acad Sci, 107, 18433, 2010.
NL4-3HIV1 Plasmid HIV-1 proviral clone expresses an internal GFP fusion and replicates in human T cell lines Hubner et al. J Virol, 81, 12596, 2007.
Name Description
Clusterin An ELISA that specifically tests for the presence of Clusterin, also known as apolipoprotein J (ApoJ), in the urine of human patients. This is the first test for determining who will develop renal impairment due to fibrosis following transplantation.
SHROOM3 Assay A RNA screen for SHROOM3 expression levels, as well as SNP risk allele prevalence, in kidney allograft biopsies. SHROOM3 has emerged independently linked to incident and prevalent chronic kidney disease (CKD) in Caucasian predominant cohorts.
KLF6-sv1 A mAb used to screen tumor biopsies for the presence of Krüppel-like family transcription factor 6, splice variant 1 (KLF6-sv1). KLF6-sv1 is potent driver of breast cancer metastasis and a prognostic marker for poor outcome in human breast cancer.
Melanoma Recurrence Assay A specialized RNA expression assay that uses Nanostring technology to predict melanoma recurrence and help physicians/patients decide on the use of imaging strategies and/or adjuvant therapies. Specially designed to be compatible with formadehyde-fixed, parrafin embedded clinical samples.
Name Description
Endoluminal Keyhole Trocar A trocar with a keyhole cutout of one end, to be inserted into the lumen of a colostomy or ileostomy. It allows for the passage of a sharp needle through the wall of the bowel while protecting the opposite bowel wall.
E-Z Drill Guide A drill guide customized for the drilling of pilot holes and screw trajectories in a consistent and optimized way for a particular type of cervical instrumentation, known as the lateral mass screw technique.
Illness Warning Instrument An instrument that allows for the recording of 12 different items (behaviors) that can be tracked per patient over time. Empowers nursing assistants to relay vital information about acute changes in a patient’s well-being aimed at early intervention in cases of acute illnesses.
Spinal Radiation Shield An implantable spinal radiation shield consisting of a thin flexible metallic film (0.1 – 0.2 mm thick) made from a dense but inert material like tantalum or gold, which protects the spinal cord from radiation injury while treating cancer with radiation therapy.
Magnetic Needle Retrieval Instrument A minimally invasive, magnetic surgical device designed to fit through standard laparoscopic, robotic and endoscopic ports to retrieve lost metal surgical needles, clips, foreign bodies, etc.
Soft Tissue Sampling Tool A disposable, cylindrically-shaped soft tissue sampling tool that is 1-2 cm in diameter and >3 cm in height, specifically designed to perform standardized biopsies of soft, spongy and inconsistent tissues that are difficult to sample by using scalpels (placenta, brain, etc.).
Patch Trocar Site Closure Device An “umbrella” type trocar site closure device consisting of small ridges and bristles on the back of the umbrella that allow it to be anchored into the peritoneal lining so that it patches the actual trocar hole preventing any herniation of bowel contents.
Ventilation Bag Microbial Sheath An impermeable, synthetic sheath covered ventilation bag that comes pre-sealed and can be incorporated/used with disposable anesthesia circuits. Reduces likelihood of patient-derived cross contamination during incubation.

We are currently taking inventory of software created at the Mount Sinai Health System. This software will be available for download, please check back soon to learn more.

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