Our Technologies

Scientists in Drs. Hoffman and Chaurasia’s laboratories have developed a novel approach to substantially expand the numbers of functional Cord blood (CB) hematopoietic stem cells (HSCs) while maintaining true stem cell engraftment capability. Cord blood (CB) cells that express CD34 have extensive hematopoietic capacity and rapidly ...

Obesity is a major public health problem. Dr. Martignetti and colleagues have described an autosomal-recessive morbid-obesity syndrome and identify the disease-causing gene defect. Homozygosity mapping localized the disease locus to a region in 3q29; we designated this region the morbid obesity 1 (MO1) locus. Sequence analysis identified a ...

This technology relates to the use of 3 biomarkers present in urine that can be used to predict kidney disease progression.  Briefly, Dr. Böttinger and colleagues have discovered a set of 3 biomarkers that can be used over time to ...

Fibrotic healing, which can cause scarring, results from the persistence of myofibroblasts. Myofibroblasts are characterized by excess cell surface expression of integrin alpha-v-beta-5 that participates in generating fibrosis through increased cell adhesion and by direct activation of the fibrotic growth factor, ...

Human cells have a multitude (hundreds to thousands) of mitochondria organelles, each carrying multiple circular mtDNA. Mutations in mtDNA can cause developmental and metabolic disorders and play a role in age-related neurological disorders, such as Alzheimer’s and Parkinson’s disease. While sequencing of nuclear DNA has become increasingly easier and less expensive, ...