Our Technologies

Enzyme replacement therapy (ERT) is the standard treatment for a number of lysosomal storage disorders (LSDs). However, this treatment is a lifelong therapy with side effects and complications that can decrease its effectiveness. More importantly these replacement proteins cannot cross the blood brain barrier, thus making them ineffective for over ...

Lymphocytes (B-cells and T-cells) are critical components to the immune system and are used to mount a defense against a foreign antigen.  Unlike B-cells, when activated trigger the production of antibodies to address the antigen, T-cell activation leads to the release of cytokines that regulate B-cells and other aspects of ...

Elucidating causal relationships between the components within complex networks has impact in commercial and research applications.  For example, the ability to understand causal relationships of the components that determine stock prices can predict how the stock market will behave.  In biomedical research, knowing the relationships between the genes within complex ...

Intracellular signaling pathways mediate cellular responses to a variety of extracellular signals and dysregulation of such pathways, especially those involved in cell growth and differentiation, is the main cause of cancer. The RAS family of proteins plays key roles in signal transduction, and mutations in RAS proto-oncogenes are involved in ...

Dr. Luca Lambertini, co-Director of the Mount Sinai Pregnancy BioBank, and Dr. Men-Jean Lee, Director of Perinatal Research in the Department of Obstetrics, Gynecology and Reproductive Science, have developed a disposable, cylindrically-shaped soft tissue sampling tool that ...