Our Technologies

SLICE-SELECTIVE ADIABATIC MAGNETIZATION PREPARATION (SAMPA) FOR T2-WEIGHTED AND DIFFUSION-WEIGHTED IMAGING
August 11, 2015

Magnetic resonance (MR) imaging at high-fields (3-4.7T) and ultra-high fields (7T and above) leads Continue reading

SEMI-ADIABATIC SPECTRAL-SPATIAL SPECTROSCOPIC IMAGING (SASSI)
August 11, 2015

Proton magnetic resonance spectroscopic imaging (MRSI) can be used as a non-invasive technique for Continue reading

MATCHED-PHASE SEMI-ADIABATIC MULTI-SLICE SPIN-ECHO PINS PULSE PAIR
August 11, 2015

There are still several challenges in acquiring high-quality MR images when using high magnetic Continue reading

TOOL COMPOUND TO TREAT INFLAMMATORY DISEASE
August 11, 2015

Rheumatoid arthritis (RA) occurs when the immune system, which normally is there to protect Continue reading

NOVEL SMALL MOLECULES FOR TREATMENT OF LYSOSOMAL STORAGE DISORDERS
July 15, 2015

Enzyme replacement therapy (ERT) is the standard treatment for a number of lysosomal storage Continue reading

NOVEL METHOD TO CHARACTERIZE THE TCR REPERTOIRE
April 30, 2015

Lymphocytes (B-cells and T-cells) are critical components to the immune system and are used Continue reading

METHOD TO DETERMINE CAUSAL RELATIONSHIPS IN COMPLEX NETWORKS
March 5, 2015

Elucidating causal relationships between the components within complex networks has impact in commercial and Continue reading

IDENTIFYING THE SUBTYPES OF LEUKEMIA BY CHARACTERIZING THE MUTATIONS OF THE PTPN11 GENE
February 25, 2015

Intracellular signaling pathways mediate cellular responses to a variety of extracellular signals and dysregulation Continue reading

SOFT TISSUE SAMPLING TOOL
August 1, 2014

Dr. Luca Lambertini, co-Director of the Mount Sinai Pregnancy BioBank, and Dr. Men-Jean Lee, Continue reading

EXPANDED CORD BLOOD STEM CELLS FOR USE AS TRANSPLANTATION GRAFTS
July 31, 2014

Scientists in Drs. Hoffman and Chaurasia’s laboratories have developed a novel approach to substantially Continue reading

NEW TARGET TO CONTROL OBESITY AND MALNUTRITION
July 9, 2014

Obesity is a major public health problem. Dr. Martignetti and colleagues have described an Continue reading

A SET OF 3 URINARY BIOMARKERS AS A PROGNOSTIC/DIAGNOSTIC FOR KIDNEY DISEASE
June 19, 2014

This technology relates to the use of 3 biomarkers present in urine that can Continue reading

siRNA THERAPY TO PREVENT OCULAR SCARRING
June 10, 2014

Fibrotic healing, which can cause scarring, results from the persistence of myofibroblasts. Myofibroblasts are Continue reading

Mseek: A METHOD TO PURIFY AND SEQUENCE MITOCHONDRIAL DNA (mtDNA)
June 10, 2014

Human cells have a multitude (hundreds to thousands) of mitochondria organelles, each carrying multiple Continue reading

THE USE OF CEACAM5 PEPTIDES AS AN IMMUNOTHERAPY FOR CROHN’S DISEASE
May 30, 2014

Crohn’s Disease (CD) is a chronic relapsing/remitting inflammatory disease of the gastrointestinal tract affecting Continue reading

SMALL MOLECULE TSHR AGONISTS AND THEIR USE IN DETECTING AND TREATING THYROID CANCERS AND OTHER THYROID DISORDERS
May 30, 2014

Thyroid cancer afflicts upwards of 60,000 patients/year in the United States and the incidence Continue reading

DOUBLE-AMPLIFICATION REFRACTORY MUTATION SYSTEM (ARMS) FOR RAPID DETECTION OF CYP2C19*4A AND *4B
May 29, 2014

Cytochrome P450 2C19 (CYP2C19) monooxygenase enzyme is involved in the hepatic metabolism of numerous Continue reading

RoSE Scale (Recognition of Smile Excursion)
May 29, 2014

At the Mount Sinai Medical Center, Drs. Elliott Rose, Peter Taub, Eric Jablonka and Continue reading

MiRad (Mobile Integrated Radiology Dosimeter)
May 29, 2014

The MiRad is a personalized portable radiation detector that is primarily designed to give Continue reading

IMPLANTABLE SPINAL RADIATION SHIELD DELIVERABLE BY OPEN OR MINIMALLY INVASIVE SURGERY
May 29, 2014

The spinal radiation shield is designed to relieve spinal cord compression caused by spinal Continue reading

CONSTRUCTION OF REASSORTMENT-DEFICIENT INFLUENZA VIRUS
May 29, 2014

An effective way to protect against influenza infection is through vaccination with attenuated influenza Continue reading

MAGNETIC NEEDLE RETRIEVER
May 29, 2014

The magnetic needle retrieval device is designed to fit through standard laparoscopic, endoscopic or Continue reading

NOVEL HIGH THROUGHPUT SCREEN TO IDENTIFY REGULATORS OF UBIQUITIN LIGASE ACTIVITY
May 29, 2014

Protein ubiquitination, a multi-step process utilizing a cascade of three enzyme classes (E1, E2 Continue reading

LOW DOSE PROTEASOME INHIBITOR SENSITIZES PI3K RESISTANT CANCERS TO TREATMENT WITH PI3K PATHWAY INHIBITORS
May 29, 2014

Resistance to PI3 kinase pathway inhibitors can occur through changes in cancer signaling pathways. “Priming” Continue reading

INSULIN-LIKE GROWTH FACTOR-1 FOR PHELIN-McDERMID SYNDROME, A RARE AUTISM-RELATED SYNDROME
May 29, 2014

Phelin-McDermid Syndrome (PMS) is a rare genetic syndrome, with a wide range of severity Continue reading

PARAMYXOVIRUSES AS VACCINE VECTORS FOR LARGE FOREIGN ANTIGENS
May 14, 2014

This technology describes a method that increases the ability of paramyxoviruses to encode a Continue reading

AN ATTENUATED EQUINE INFLUENZA VIRAL VECTOR
May 14, 2014

By introducing specific truncations into the NS1 gene of the equine influenza virus, Dr. Continue reading

INHIBITION OF TNF ALPHA ACTIVATION OF NFKB BY PENTOSAN POLYSULFATE
May 14, 2014

Researchers have discovered that Pentosan polysulfate acts through inhibiting TNF-alpha-mediated NFKB activation, and that Continue reading

METHODS FOR PROGRAMMING DIFFERENTIATED CELLS INTO HEMATOPOIETIC STEM CELLS
May 14, 2014

This technology defines a specific combination of transcription factors that can program hemogenesis in Continue reading

SUTURE-FREE TROCAR SITE CLOSURE DEVICE
May 14, 2014

The trocar site closure device is designed to rapidly close trocar (port) sites without Continue reading

GENIPIN-CROSSLINKED FIBRIN HYDROGEL FOR SOFT TISSUE REPAIR
May 14, 2014

The genipin-crosslinked fibrin hydrogel (FibGen) is a stiff, biocompatible hydrogel intended to fill tissue Continue reading

POTENT NEUTRALIZING MONOCLONAL ANTIBODIES TO HCMV
May 14, 2014

This technology relates to a Human Cytomegalovirus (HCMV) neutralizing monoclonal antibody that is significantly Continue reading

HIGH-THROUGHPUT ASSAY FOR INHIBITORS OF HIV’S CELL-TO-CELL TRANSMISSION
May 14, 2014

This technology allows the identification of a new class of antiviral drugs that inhibit Continue reading

A VERSATILE IN VIVO RNA-INTERFERENCE DELIVERY PLATFORM
May 14, 2014

The ability to deliver miRNAs or small interfering RNAs (siRNAs) in vivo has been Continue reading

IN VIVO RNAi SCREEN FOR THE IDENTIFICATION OF HOST FACTORS RESTRICTING VIRAL REPLICATION
May 14, 2014

This technology allows the identification of host restriction factors that limit viral replication in Continue reading

A NOVEL TARGETABLE FGFR2 GENE FUSION IN CHOLANGIOCARCINOMA
May 14, 2014

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with very poor prognosis. Surgical resection is Continue reading

USE OF IMATINIB TO TREAT HEPATIC FIBROSIS
May 14, 2014

There is a huge potential economic impact of establishing a treatment for hepatic fibrosis. Continue reading

NOVEL LIVE ATTENUATED INFLUENZA VIRUS VACCINES
May 14, 2014

This technology takes advantage of the species-specific expression of miRNAs to generate live attenuated Continue reading

A NOVEL THERAPEUTIC TARGET FOR RAF1-ASSOCIATED DILATED CARDIOMYOPATHY
May 14, 2014

Dilated cardiomyopathy (DCM) is a highly heterogeneous trait with sarcomeric gene mutations predominating. The Continue reading

MEDIATION OF ANTIVIRAL ACTIVITY BY X-DING-CD4 PEPTIPE (SIMM et al)
May 12, 2014

Viral infections are hard to treat and at present, there are few licensed antivirals Continue reading

MODIFIED VERO CELLS WITH SUPPRESSED INNATE IMMUNE RESPONSES AND ENHANCED VIRUS PRODUCTION
May 12, 2014

Dr. Chris Basler and colleagues have developed a stable cell line with enhanced virus Continue reading

NOVEL THERAPIES TARGETING SUMO-1 FOR THE TREATMENT OF HEART FAILURE
May 12, 2014

Congestive heart failure (HF) is a devastating, progressive disease with poor prognosis. As the Continue reading

ANTI-LILRB3 (ILT5) MONOCLONAL ANTIBODIES FOR TUMOR IMMUNOTHERAPY
May 12, 2014

Myeloid cells represent a major component of tumor microenvironments in patients where they promote Continue reading

ANTIBODIES TARGETING FOLLICLE STIMULATING HORMONE FOR USE IN OSTEOPOROSIS TREATMENT AND PREVENTION
May 2, 2014

A new paradigm for osteoporosis prevention and treatment was described by Dr. Mone Zaidi, Continue reading

DIETARY ISOFLAVONES – A TREATMENT OPTION FOR FOOD ALLERGY
May 2, 2014

Food allergy impacts the life and life style of an estimated 12 million Americans. Continue reading

GENE EXPRESSION SIGNATURE FOR GUIDING THERAPY DECISIONS IN PATIENTS WITH RESECTED STAGE II-III CUTANEOUS MELANOMAS
May 2, 2014

Patients with resected stage II-III cutaneous melanomas remain at high risk for metastasis and Continue reading

NOVEL BROMODOMAIN (BRD4) SMALL MOLECULE INHIBITORS FOR TARGETED TREATMENT OF CANCER
April 25, 2014

Bromodomain-containing proteins function as chromatin modifiers and mediators of protein-protein interactions, controlling gene expression. Continue reading

NOVEL THERAPY FOR TREATMENT OF HEMOGLOBINOPATHIES (BETA-THALASSEMIA AND SICKLE CELL DISEASE)
April 24, 2014

Thalassemias are the result of the most common single gene genetic disorder worldwide, affecting Continue reading

PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA AND NOTCH3 RECEPTOR MODULATORS FOR THE TREATMENT OF INFANTILE MYOFIBROMATOSIS
April 24, 2014

Infantile myofibromatosis (IMF) is one of the most common proliferative fibrous tumors of infancy Continue reading

NOVEL MICRO-RNA THERAPY FOR TREATMENT OF DRAVET SYNDROME, A PEDIATRIC ORPHAN DISEASE
April 24, 2014

Dravet syndrome (DS), also known as severe myoclonic epilepsy of infancy (SMEI), is a Continue reading

USE OF FLUOXETINE TO TREAT AUTISM SPECTRUM DISORDER
April 24, 2014

Autism spectrum disorder (ASD) is a collection of development disorders characterized by difficulties in Continue reading

USE OF MEMANTINE TO TREAT AUTISM AND ASSOCIATED DISORDERS
April 24, 2014

Autism spectrum disorder (ASD) is a collection of development disorders of unknown etiology characterized Continue reading

NOVEL THERAPY TO REDUCE SUICIDAL IDEATION ASSOCIATED WITH SSRI USE
April 23, 2014

Major Depressive Disorder (depression) is a mental disorder with symptoms including low mood, low Continue reading

A NOVEL METHOD TO TREAT ALZHEIMER’S DISEASE AND TUMOR METASTASIS
March 25, 2014

Alzheimer's disease (AD) is the most common age-associated dementia. It is a progressive neurodegenerative Continue reading

NOVEL METHOD TO SPECIFICALLY INHIBIT CATHEPSIN K COLLAGENOLYTIC ACTIVITY
March 19, 2014

Bone homeostasis is a complex process and requires a balance between bone formation and Continue reading

DNA LOCK™: A NOVEL AND SECURE DNA-BASED AUTHENTICATION METHOD
March 19, 2014

Seized, counterfeit goods in the United States in 2012 were estimated to be worth Continue reading