Posts Tagged ‘Autoimmune/Inflammation’

Crohn’s Disease (CD) is a chronic relapsing/remitting inflammatory disease of the gastrointestinal tract affecting about 800,000 patients in the US and Europe alone with rising incidence rates. In addition to reduced quality of life for CD patients, the chronic inflammation associated with CD ultimately leads to neoplasia, strictures, abscesses, and ...

Myeloid cells represent a major component of tumor microenvironments in patients where they promote tumor growth/metastasis while suppressing anti-tumor adaptive immunity. LILRB3 is an immunomodulatory receptor uniquely expressed on myeloid cell populations including monocytes, macrophages, DCs, and granulocytes and researchers at Mount Sinai in the laboratory of Dr. ...

To date, a major limiting factor for the use of MDSCs in certain therapies – in pathological settings where deleterious or excessive immune responses need to be avoided or reduced – is the source of MDSCs. Mount Sinai researchers demonstrated efficient in vitro derivation of MDSCs from embryonic stem cells ...

Emerging evidence suggests that MDSCs have great potential as an immune intervention modality in both transplantation and autoimmune disease settings. Mount Sinai investigators demonstrated their utility in both GVHD and Type 1 Diabetes. Coupled with a suite of other pending patent applications including a protocol for expansion and differentiation of ...

Bromodomain-containing proteins function as chromatin modifiers and mediators of protein-protein interactions, controlling gene expression. BRDs have been functionally implicated in numerous disease processes, including cancer, and small molecule inhibitors have been developed with some advancing to early clinical trials in cancer. ...

Bone homeostasis is a complex process and requires a balance between bone formation and resorption.  Cathepsin K is a collagenase which is highly expressed in bone resorbing cells and its deficiency leads to pycnodysostosis, a rare disease characterized by a decrease in bone resorption. Osteoporosis, a disease in which bones ...