Posts Tagged ‘Basic Research’

Dr. Luca Lambertini, co-Director of the Mount Sinai Pregnancy BioBank, and Dr. Men-Jean Lee, Director of Perinatal Research in the Department of Obstetrics, Gynecology and Reproductive Science, have developed a disposable, cylindrically-shaped soft tissue sampling tool that ...

Human cells have a multitude (hundreds to thousands) of mitochondria organelles, each carrying multiple circular mtDNA. Mutations in mtDNA can cause developmental and metabolic disorders and play a role in age-related neurological disorders, such as Alzheimer’s and Parkinson’s disease. While sequencing of nuclear DNA has become increasingly easier and less expensive, ...

The ability to deliver miRNAs or small interfering RNAs (siRNAs) in vivo has been a major hurdle in harnessing the power of RNA interference. This platform technology employs RNA virus-like vectors to deliver functional small RNAs to any tissue of interest. Depending on the application desired, vectors can be enabled for ...

This technology allows the identification of host restriction factors that limit viral replication in a relevant animal model. Standard siRNA screens are most often conducted in vitro using transformed cell lines and are therefore inherently non-physiological. However, by enabling siRNA delivery through replication-competent RNA viruses, natural selection can be harnessed to ...

Dr. Chris Basler and colleagues have developed a stable cell line with enhanced virus replication and production efficiency. The Vero 76 cell line (ATCC No. CCL-1587) has been widely used for cell-based research and product development (1, 2, 4). Several characteristics of Vero 76 cells make them particularly ...

Seized, counterfeit goods in the United States in 2012 were estimated to be worth over $1.30 billion. Current marking techniques can be recovered, copied and illegally used to mark counterfeited goods. To control this increasing problem, reliable counterfeit-resistant techniques are required. Scientists Carter Bancroft and Catherine Clelland ...