Posts Tagged ‘Infectious Disease’

An effective way to protect against influenza infection is through vaccination with attenuated influenza virus. However, due to reassortment, co-infection of an individual with a live attenuated vaccine strain and a wild-type strain of influenza may enable formulation of replication-competent virus carrying the vaccine derived hemagglutinin, to which an infected ...

This technology describes a method that increases the ability of paramyxoviruses to encode a large foreign antigen for development of vaccines. Recombinant paramyxoviruses encoding small foreign antigens have been successful at eliciting specific cellular and immune responses and some have also been used as oncolytic viruses. Paramyxoviruses are single stranded RNA ...

By introducing specific truncations into the NS1 gene of the equine influenza virus, Dr. Garcia-Sastre and colleagues have produced a live-attenuated virus that serves as a flexible platform for the prevention and treatment of infectious diseases, as well as other IFN-treatable conditions, such as cancer.  Fundamentally, this vector ...

This technology relates to a Human Cytomegalovirus (HCMV) neutralizing monoclonal antibody that is significantly more potent than the currently marketed alternative Cytogam™. HCMV infection is typically unnoticed in healthy people, but can be life-threatening for the immunocompromised, such as HIV patients, organ transplant recipients, or newborn infants. Congenital infection with HCMV ...

This technology allows the identification of a new class of antiviral drugs that inhibit the transmission of the Human Immunodeficiency Virus (HIV) through the virological synapse. Although there are several effective treatments for HIV, it continues to remain an incurable condition that leads to failure and death in the absence of ...

This technology takes advantage of the species-specific expression of miRNAs to generate live attenuated influenza virus vaccines (LAIVs) alleviating all manufacturing constraints and the necessity of relying on cold-adapted mutants. This technology is enabled by the silent insertion of perfect miRNA target sites to control the level and location of virus ...

Viral infections are hard to treat and at present, there are few licensed antivirals available to patients. In addition, many patients develop resistance to the currently available antivirals. Thus, new antivirals are needed to provide patients with better and more effective options for prevention and therapy. Dr. Malgorzata Simm ...

Dr. Chris Basler and colleagues have developed a stable cell line with enhanced virus replication and production efficiency. The Vero 76 cell line (ATCC No. CCL-1587) has been widely used for cell-based research and product development (1, 2, 4). Several characteristics of Vero 76 cells make them particularly ...