Posts Tagged ‘Metabolic Disease’

Obesity is a major public health problem. Dr. Martignetti and colleagues have described an autosomal-recessive morbid-obesity syndrome and identify the disease-causing gene defect. Homozygosity mapping localized the disease locus to a region in 3q29; we designated this region the morbid obesity 1 (MO1) locus. Sequence analysis identified a ...

Cytochrome P450 2C19 (CYP2C19) monooxygenase enzyme is involved in the hepatic metabolism of numerous drugs. CYP2C19 is highly polymorphic and mutations lead to varying metabolic capacity, affecting appropriate therapeutic dosing. There are existing commercial products that assess the CYP2C19 genotype for common alleles related to a patient’s ability to metabolize ...

It has long been known that estrogen function in women decreases with age. While estrogen levels are decreased in aging, the levels remain sufficient to stimulate estrogen receptors, suggesting that the reason for the insensitivity to estrogen is due to the decrease in number and function of estrogen receptors that ...