Posts Tagged ‘Oncology’

Scientists in Drs. Hoffman and Chaurasia’s laboratories have developed a novel approach to substantially expand the numbers of functional Cord blood (CB) hematopoietic stem cells (HSCs) while maintaining true stem cell engraftment capability. Cord blood (CB) cells that express CD34 have extensive hematopoietic capacity and rapidly ...

Thyroid cancer afflicts upwards of 60,000 patients/year in the United States and the incidence rate is rising worldwide. The current standard of care includes surgical thyroidectomy followed by radioactive iodine ablation to destroy any remaining thyroid tissue. As thyroid cancer patients ...

Protein ubiquitination, a multi-step process utilizing a cascade of three enzyme classes (E1, E2 and E3), tightly regulates cellular protein turnover. It plays a key role in cellular proliferation and inflammation and is associated with a multitude of diseases, including cancer, metabolic disorders, and muscle and nerve degeneration. Dr. ...

Resistance to PI3 kinase pathway inhibitors can occur through changes in cancer signaling pathways. “Priming” with subtherapeutic doses bortezomib leads to activation of and reliance on the PI3 kinase pathway, making cancers susceptible to PI3 kinase pathway inhibitors. Dr. Ross Cagan and members of his laboratory at Mount Sinai’s Center ...

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with very poor prognosis. Surgical resection is the only potentially curative therapy for ICC patients, but most of them are diagnosed at advanced stage, when only palliative chemotherapy is available. Furthermore, even when curative resection is feasible, intrahepatic recurrence is highly frequent, worsening ...

Dilated cardiomyopathy (DCM) is a highly heterogeneous trait with sarcomeric gene mutations predominating. The cause of a substantial percentage of DCMs remains unknown, and no gene-specific therapy is available. Currently, the available medical therapies are supportive and the only surgical alternative is heart transplantation, a drastic step with numerous morbidities ...

Dr. Chris Basler and colleagues have developed a stable cell line with enhanced virus replication and production efficiency. The Vero 76 cell line (ATCC No. CCL-1587) has been widely used for cell-based research and product development (1, 2, 4). Several characteristics of Vero 76 cells make them particularly ...

Myeloid cells represent a major component of tumor microenvironments in patients where they promote tumor growth/metastasis while suppressing anti-tumor adaptive immunity. LILRB3 is an immunomodulatory receptor uniquely expressed on myeloid cell populations including monocytes, macrophages, DCs, and granulocytes and researchers at Mount Sinai in the laboratory of Dr. ...

Patients with resected stage II-III cutaneous melanomas remain at high risk for metastasis and death. Biomarker development has been limited by the challenge of isolating high-quality RNA from formalin-fixed and paraffin-embedded (FFPE) primary tumors. Using NanoString, RNA from 40 stage II-III FFPE primary melanomas was analyzed and a 53-immune-gene panel ...

Bromodomain-containing proteins function as chromatin modifiers and mediators of protein-protein interactions, controlling gene expression. BRDs have been functionally implicated in numerous disease processes, including cancer, and small molecule inhibitors have been developed with some advancing to early clinical trials in cancer. ...